Risk of myocarditis and pericarditis, increased with # of doses, moderna, male, age 12 to 50
We estimated the number of excess cases attributable to vaccines by sex and age group (Fig. 3). The number of excess cases of myocarditis per 100,000 doses administered to adolescent males 12 to 17 years was 1.9 (95% CI, 1.4–2.6) for the second dose of the BNT162b2 vaccine and for young adults 18 to 24 years of age reached 4.7 (95% CI, 3.8–5.8) for the second dose of the BNT162b2 vaccine, and 17 (95% CI, 13–23) for the second dose of the mRNA-1273 vaccine (Fig. 3). This translates into one case of vaccine-associated myocarditis per 52,300 (95% CI, 38,200–74,100) second doses of the BNT162b2 vaccine among 12–17 years, and 21,100 (95% CI, 17,400–26,000) second doses of the BNT162b2 vaccine and 5900 (95% CI, 4400–8000) second doses of the mRNA-1273 vaccine among 18–24 years (Table S5). Estimates of excess cases were lower for older age groups and generally for females. However, the number of excess cases of myocarditis attributable to the second dose of the mRNA-1273 vaccine was consistently higher. Among females aged 18 to 24 years, the estimated number of excess cases of myocarditis per 100,000 doses reached 0.63 (95% CI, 0.34–1.1) for the second dose of the BNT162b2 vaccine (corresponding to 1 case per 159,000 [95% CI, 90,800–294,400] doses) and 5.3 (95% CI, 3.0–9.1) for the second dose of the mRNA-1273 vaccine (corresponding to 1 case per 18,700 [95% CI, 11,000–33,400] doses). The number of excess cases of pericarditis is presented in Fig. 3. As for myocarditis, estimates for the second dose of the mRNA-1273 vaccine were consistently higher.